Functionalized Oxindole Construction via a Cyano Migration and Cyclization Relay Strategy
Bo-Xi Liu1,5,Syed Anis Ali Shah1, Feng Zhou1, Weidong Rao2, Shu-Su Shen3, Daopeng Sheng4, Shun-Yi Wang1,5（汪顺义）*
1Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University,Suzhou 215123, China
2Key Laboratory of Biomass-based Green Fuels and Chemicals, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China
3School of Environmental Science and Engineering, Suzhou University of Science and Technology,Suzhou 215009, P. R. China
4State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences(RAD-X), Soochow University, Suzhou, Jiangsu 215123, China
5Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions,Soochow University, Suzhou, Jiangsu 215123, China
Org. Lett.2025, 27, 4656–4662
Abstract: A visible-light-induced trifunctionalization of unactivated alkenes for building functionalized oxindoles through a radical cyano migration strategy is reported. This transformation employs a tandem alkene sulfonylation-initiated cyano migration/cyclization cascade process. This strategy features stable and easily accessible substrates, mild reaction conditions, metal-free catalysts, and the capability of late-stage functionalization.
Article information: //doi.org/10.1021/acs.orglett.5c00899
