Visible-Light Induced Etherification of C(sp3)-H Bonds with Phenols
Qian Jing, Zelin Zhao, Xin Fang, Xin-Hua Lu, David J. Young, Zhi-Gang Ren, Hong-Xi Li（李红喜）*
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, People’s Republic of China
Org. Lett. 2025, 27, 4848–4852
Abstract: The visible-light induced cross-dehydrogenative coupling of C(sp3)–H bonds with phenols using BrCCl3 to give aryl alkyl ethers has been achieved under transition-metal- and photocatalyst-free conditions. This operationally simple and mild protocol has a broad substrate scope, and was applied to the modification of drug molecules and on a gram-scale synthesis. The phenolate ion functions as both a substrate and photosensitizer, and BrCCl3 serves as the oxidant and hydrogen atom transfer (HAT) agent.
Article information: //doi.org/10.1021/acs.orglett.5c01018
